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The results in overdosage will probably be potentiated by simultaneous ingestion of Liquor and psychotropic medications.

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The individuals needs to be followed intently for indications and signs and symptoms of respiratory depression and sedation. Within this respect, it can be strongly advised to tell people as well as their caregivers to be familiar with these symptoms (see segment four.five).

The length of therapy really should be limited to 3 times and if no successful pain relief is achieved the sufferers/carers need to be encouraged to seek the views of the medical doctor.

Supplemental support and checking could possibly be essential when prescribing for sufferers vulnerable to opioid misuse.

Opioid analgesics really should be prevented in patients with biliary tract disorders or employed at the side of an antispasmodic.

Applying this medicine with any of the following might result in an elevated threat of particular Negative effects but might be unavoidable sometimes. If used jointly, your doctor could click here change the dose or how often you utilize this medication, or Provide you with Exclusive Guidance about the use of foodstuff, Alcoholic beverages, or tobacco.

Sodium oxybate: concomitant administration of codeine and sodium oxybate could cause increased CNS melancholy and/or respiratory depression and/or hypotension.

- Cimetidine inhibits the metabolism of opioid analgesics producing increased plasma concentration of codeine

Immune method disorders: maculopapular rash has been found as A part of a hypersensitivity syndrome associated with oral codeine phosphate; fever, splenomegaly and lymphadenopathy also transpired.

The overall prevalence of sulfite sensitivity in the overall inhabitants is unidentified and doubtless reduced. Sulfite sensitivity is viewed much more regularly in asthmatic than in nonasthmatic people.

Acetaminophen and codeine phosphate tablets are indicated with the relief of mild to moderately serious ache.

Drug withdrawal click here syndrome Just before commencing therapy with any opioids, a dialogue needs to be held with patients to put set up a withdrawal approach for ending treatment with codeine.

Anti-arrhythmics: codeine delays the absorption of mexiletine. The analgesic exercise of codeine is likely being drastically impaired by quinidine which impairs codeine metabolism.